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Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinson's disease

Therefore, the ability to replicate human physiological complexity more accurately by modulating the 3D microenvironment, and applying various physical stimuli, underscores the significant value of OoC technology across several pivotal areas of research, from pathophysiology studies to personalized therapeutics

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As a major source of ROS, primarily superoxide, generated as byproducts of OXPHOS at Complexes I and III [3], mitochondria possess antioxidant systems including superoxide dismutase 2, glutathione peroxidase, and catalase to neutralize ROS